Give differences : Haemophilia and Sickle-cell Anaemia
Haemophilia | Sickle-cell Anaemia |
$(1)$ It occur due to a defective recessive allele present on the $X$-chromosome. | $(1)$ It occurs due to point mutation i.e. a single base pair change leads to a change in amino acid. |
$(2)$ The defective allele produce nonfunctional protein which later form a non-functional protein which later form a non-functional cascade of protein involving in blood clotting | $(2)$ In this glutamic ($Glu$) acid is replaced by Valine ($Val$) at sixth position of beta globin chain of haemoglobin molecule. |
$(3)$ It is a sex-linked recessive disorder. | $(3)$ It is an autosomal linked recessive disorder. |
$(4)$ More males are affected than females. | $(4)$ Both males and females are affected equally. |
Haemolytic jaundice is caused due to a dominant gene but only $10\%$ of the people actually develop the disease. A heterozygous man marries a homozygous normal woman; what proportion of the children would be expected to develop the haemolytic disease
Genes for colour blindness is carried by
$I.$ Abnormal development
$II.$ Father
$III.$ Mother
$IV.$ Autosomes
A normal woman whose father was colourblind marries a normal man. What kinds of children would be expected and in what proportion
Describe pedigree analysis and draw its symbols.
In the above pedigree, assume that no outsider marrying in, carry a disease. Write the genotypes of $C$ and $D$.