Give differences : Haemophilia and Sickle-cell Anaemia
Haemophilia | Sickle-cell Anaemia |
$(1)$ It occur due to a defective recessive allele present on the $X$-chromosome. | $(1)$ It occurs due to point mutation i.e. a single base pair change leads to a change in amino acid. |
$(2)$ The defective allele produce nonfunctional protein which later form a non-functional protein which later form a non-functional cascade of protein involving in blood clotting | $(2)$ In this glutamic ($Glu$) acid is replaced by Valine ($Val$) at sixth position of beta globin chain of haemoglobin molecule. |
$(3)$ It is a sex-linked recessive disorder. | $(3)$ It is an autosomal linked recessive disorder. |
$(4)$ More males are affected than females. | $(4)$ Both males and females are affected equally. |
Give scientific reasons : The Mendelian experiments cannot be carried out in human beings.
Colour blindness in man is
A normal visioned woman, whose father is colour blind, marries a normal visioned man. What would be probability of her sons and daughters to be colour blind ? Explain with the help of a pedigree chart.
Give scientific reasons : The human male never passes on the gene for haemophilia to his son.