Give differences : Haemophilia and Sickle-cell Anaemia
Give differences : Haemophilia and Sickle-cell Anaemia
| Haemophilia | Sickle-cell Anaemia |
| $(1)$ It occur due to a defective recessive allele present on the $X$-chromosome. | $(1)$ It occurs due to point mutation i.e. a single base pair change leads to a change in amino acid. |
| $(2)$ The defective allele produce nonfunctional protein which later form a non-functional protein which later form a non-functional cascade of protein involving in blood clotting | $(2)$ In this glutamic ($Glu$) acid is replaced by Valine ($Val$) at sixth position of beta globin chain of haemoglobin molecule. |
| $(3)$ It is a sex-linked recessive disorder. | $(3)$ It is an autosomal linked recessive disorder. |
| $(4)$ More males are affected than females. | $(4)$ Both males and females are affected equally. |
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